CYP2D6 and cancer: Considering the other single nucleotide variants in these patients, we identified on average 17 additional cancer-related variants per patient in 43 different genes in patient samples with the PAX5alt and PAX5 P80R subtypes, the most commonly altered genes being ATM, ATRX, CYP2D6, CYP2D7, KDM5A, KMT2A, and NCOR1 (see Supplementary Table S3).