POLE and neoplasm: Initially proposed by The Cancer Genome Atlas (TCGA) based on mutation profiles, microsatellite stability, somatic copy number alterations, and tumor mutation burden, endometrial carcinoma was classified into the following four molecular groups: (1) DNA polymerase ɛ (POLE)-mutant (POLEmut/ultramutated); (2) microsatellite instability (MSI)-high (hypermutated); (3) copy number low; and (4) copy number high/serous-like carcinomas.