TP53 and neoplasm: Pathologists are generally familiar with the identification of p53 mutation patterns [87], which include (1) overexpression, characterized by diffuse, strong nuclear positivity involving at least 80% of tumor cells; (2) “null” pattern, characterized by complete absence of nuclear staining; (3) cytoplasmic, characterized by cytoplasmic staining accompanied by variable nuclear staining; and (4) heterogeneous pattern, in which different clones show different staining patterns [87].