ATM and non-small cell lung carcinoma: This study assessed the prevalence of iPGVs in NSCLC within the predominantly Hispanic/Latinx population in South Florida, U.S. These data demonstrate that germline alterations in the homologous recombination repair pathway (namely, ATM, BRCA2, and BRCA1) among Hispanic/Latinx patients with NSCLC are not uncommon at 2.54%, a rate nearly double that observed in the non-Hispanic/Latinx and non-Ashkenazi Jewish populations represented in our cohort.