GPT and Myalgia: Of nine patients who discontinued the study due to AEs (5 in continuous dosing, 1 in intermittent schedule A, and 3 in intermittent schedule B), five had AEs considered to be treatment-related (fatigue (2 in continuous dosing and 1 in schedule B) and ALT/AST increased, myalgia, polyuria, pollakiuria (all in schedule B)) (Table 6).