Anti-PD-1, anti-PDL1, and anti-CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) are monoclonal antibodies against these ligands and receptors and proved to be effective in inducing tumor regression in different tumors, especially when combined with other traditional anti-cancer drugs [9,10,11,12,13,14]. The gene discussed is CTLA4; the disease is neoplasm.