Notably, various miRNAs downregulated in cHL, including miR-20b-5p, miR-34b, miR-138-5p, miR-148a-3p, miR-340-5p, miR-455-5p, and miR-766-5p, were shown to suppress PD-L1 expression in different cancer cell types [75,76,77,78,79,80,81,82,83,84]. The gene discussed is CD274; the disease is classic Hodgkin lymphoma.