NF1 and Cafe-au-lait spot: Per the revised diagnostic criteria for NF1, the condition is characterised by café-au-lait macules (CALMs), freckling in the axillary or inguinal region, neurofibromas and plexiform neurofibromas, optic pathway gliomas (OPGs), iris Lisch nodules, osseous lesions including sphenoid dysplasia, anterolateral tibial bowing, pseudoarthrosis of a long bone, and a heterozygous pathogenic NF1 variant [2].