TERT and thyroid gland papillary carcinoma: Furthermore, a Colombian study investigating 141 papillary thyroid cancer cases showed that the BRAF V600E and TERT C228T or C250T mutations were associated with large tumors, lymph node metastasis, extra-thyroid extension, and advanced stages, and compared to published data on U.S. white people, Colombian patients had a higher prevalence of both severe pathologic features and double-mutant tumors [46].