CCND1 and plasma cell myeloma: Also, butein has been extensively tested and has been shown to inhibit the expression of Bcl-xL, Bcl-2, cyclin D1, and Mcl-1 in multiple myeloma cell lines (U266) [61], and the expression of cyclin D1, Bcl-2, Bcl-xL, survivin, and VEGF in a liver cancer cell line (HepG2) [40].