Another example is the study by Cykowiak et al., which showed that the combination of xanthohumol and phenethyl isothiocyanate decreased STAT3 levels and the activation of NF-κB and subsequently reduced COX-2 in pancreatic cancer cells (PSN-1), which indicated their anti-inflammatory and pro-apoptotic activities [96]. The gene discussed is PTGS2; the disease is familial pancreatic carcinoma.