FLT3 and acute myeloid leukemia: Fms-like tyrosine kinase 3 (FLT3) is mutated in approximately 30% of adult AML cases, including internal tandem duplication (FLT3-ITD) and tyrosine kinase domain (TKD) amino acid substitution (FLT3-TKD), leading to constitutive tyrosine kinase activity and constitutive activation of the downstream proliferative signaling cascade [48].