ACSL4 and central nervous system cancer: For instance, in isocitrate dehydrogenase-1 (IDH1) mutant gliomas, decreased triglycerides and sphingolipids have been demonstrated to be fewer in quantity relatively to IDH1 wild type gliomas, which may have been attributed to lower levels of long-chain acyl-CoA synthetase (ACS) 1, ACS4, and very long-chain ACS3 [68].