Although the co-occurrence of KRAS mutations and RET fusions in CRC is historically considered rare and literature to date consistently reports RET fusions exclusively in the context of KRAS wild-type tumors, genetic combinations, including variances of unknown significance like the fusion reported here, can indeed occur, suggesting that the interplay of genetic alterations is more complex than previously understood. The gene discussed is KRAS; the disease is colorectal carcinoma.