To date, numerous BPAN models, such as mouse, Drosophila, Caenorhabditis elegans, and Dictyostelium models, as well as human cell lines, including fibroblasts, lymphoblasts, neuroblastoma cells and induced pluripotent stem cells (iPSCs), generated from BPAN human fibroblasts, have been used to study the function of WDR45 and its homologs in the maintenance of cell homeostasis [6]. The gene discussed is WDR45; the disease is neuroblastoma.