NLRP3 and Hyperglycemia: Two high glucose concentrations were used, i.e.; 15mM (MG15 macrophages), to mimic a state of hyperglycemia, a risk factor for many diseases (e.g.; ischemic cardiovascular injuries [36], renal diseases [37], sepsis [38], cancer [39] and diabetes), and 30mM (MG30 macrophages), known to activate the NLRP3 inflammasome in M0 THP-1 macrophages, to mimic a state of a persistent inflammatory response (e.g.; in chronic wounds).