MAPK3 and non-small cell lung carcinoma: While a connection between YAP1 and MAPK3/1 (ERK1/2) has not been investigated in cardiolaminopathy, findings from non-small cell lung cancer cells indicate a positive correlation between the level of MAPK3/1 (ERK1/2) activation and YAP1 protein and target gene, including the cellular communication network factor 2 (CCN2, also known as CTGF) transcription levels [81].