CCR7 and neoplasm: The abilities of cell migration and invasion were increased significantly when PCI-4B and PCI-37B cells were co-cultured with M2 macrophages; however, when we pretreated M2 macrophages with CCR7 mAb, the migration and invasion abilities of tumor cells (PCI-4B, PCI-37B) were significantly decreased (Fig. 6a, b).