Notably, we identified several instances of cell type-specific regulon activation in T1DM: TCF7, LEF1, ETS1, and KLF2 in T/NK cells, MEF2C and PCX5 in B cells, and IRF5 in monocytes (Fig. 3e, orange; Additional file 1: Fig. S3c, g, k). This evidence concerns the gene KLF2 and type 1 diabetes mellitus.