PTPN22 and type 1 diabetes mellitus: In this case, DEGs in effector T cells (CD8+ T, MAIT, and VD2p) emerged as significantly enriched for T1DM heritability: PTPN22, KLRG1, ICAM3, CLECC2D, CDC37, CD69, CD3G, and IL7R (Fig. 6a lower panel, b).