Bovée et al. [49] researched the expression of growth factors in the epithelial and fibrous portions of AD; they concluded that both the epithelial and fibrous components express fibroblast growth factor receptor-1 and fibroblast growth factor-2, but only the epithelial tissue elements express high levels of epidermal growth factor receptor and epidermal growth factor [49]. The gene discussed is EGFR; the disease is Alzheimer disease.