However, in logistic regression analysis adjusted for age, gender, and comorbidities, NLR reached statistical significance with an odds ratio of 4.46 (95% CI = (3.53–5.40), P < 0.001), and the CRP-NLR association accounted for a 7.28 (95% CI = (4.83–10.16), P < 0.001) higher risk for severe OI. Here, CRP is linked to osteogenesis imperfecta.