COPS5 and ovarian neoplasm: About 100 DUBs have been identified in humans, which can be divided into six families:: ubiquitin-specific proteases (USPs), ovarian tumor proteases (OTUs), ubiquitin C-terminal hydroxylases (UCHs), Machado-Josephin domain proteases (MJDs), Jab1/Mov34/Mpr1 Pad1 N-terminal+ proteases (JAMMs), motif interacting with ubiquitin-containing novel DUB family proteases (MINDYs), and zinc finger containing ubiquitin peptidase 1 (ZUP1) [42].