The study that was done by Bansal & Yadav also found that large size tumor (> 5 cm) are ER negative [30, 38] but Ritu Yadav found that intermediate size of the tumor most of them are PR negative (p = 0.040) [38] reveals that growth of the tumor is depended on multiple factors not only ER and PRs but it can be one of the important one. This evidence concerns the gene PGR and neoplasm.