He demonstrated ER positive 218 (42.8%) and PR positive 194 (31.8%), but Sohail SK reported positivity for ER and PR receptors in invasive breast carcinoma 70%-80% and 60%-70%, respectively in Pakistan [21], similar results were found by Shafaq Mujtaba in Pakistan [9]. The gene discussed is ESR1; the disease is invasive breast carcinoma.