ESR1 and neoplasm: The study that was done by Bansal & Yadav also found that large size tumor (> 5 cm) are ER negative [30, 38] but Ritu Yadav found that intermediate size of the tumor most of them are PR negative (p = 0.040) [38] reveals that growth of the tumor is depended on multiple factors not only ER and PRs but it can be one of the important one.