Moreover, the NF-κB signaling pathway has been implicated in immunosuppression and immune evasion in ovarian cancer cells partly via NFκB-dependent production of IL-6, which impairs DCs but generates and recruits immunosuppressive MDSCs, and IL-8, which increases the expression of the immunosuppressive enzyme arginase [102]. This evidence concerns the gene NFKB1 and ovarian carcinoma.