CD8A and neoplasm: In terms of treatments, epigenetic therapy, including treatment with DNA methyltransferase and histone deacetylase inhibitors (DNMTis and HDACis, respectively), can increase the numbers of CD45 + immune cells, active CD8 + T cells and NK cells in the TME, reducing immunosuppression and the tumor burden through activation of type I interferon signaling in murine ovarian cancer [171, 172].