18 out of the 30 identified DNAms in DSCCN (MED27,GNG7, ST6GLNAC4,RP11,DICER1, TCF12, ZNRF3, APOA5, CERS2,TRPM1,TATDN1,LSM2,ECI2,FBXW4,TRERF1,FRY,GPLD1,FLT1) have been confirmed to be associated with breast cancer. The gene discussed is ZNRF3; the disease is breast carcinoma.