TGFB1 and neoplasm: Moreover, a variety of tumorigenic events prevent TGFβ signaling to mediate growth arrest in cancer cells, including loss of CDKN1A activation through Akt-mediated FOXO regulation, or Miz1 impairment of Myc activity impairing CDKN2B expression, resulting in a loss of the cytostatic effect of TGFβ signaling in tumor cells (reviewed in2,3,6).