C3 and osteosarcoma: Six of these genes are increased (MYOM2, VEGFA, MUC1, IHH, GLI1 and GRIA1) and seven are decreased (VCAM1, EGFR, GPC3, IGF2, GNG12, GNGT1 and C3) in localized patients with poor prognosis that either relapse or die due to osteosarcoma (Fig. 2C).