We found that the majority of hybrid cell subpopulations in peripheral blood were not represented in the tumor tissue, for example, in the CRC samples B2 was defined by higher expression of CD45, VWF, and pAKT and B7 was defined by high expression of CK8, αSMA, and Ki67 (Fig. 4A). The gene discussed is ACTA1; the disease is colorectal carcinoma.