Interestingly, in both CRC and PDAC samples, we identified hybrid subpopulations that were conserved across the tumor tissue and the peripheral blood, which were both driven by vimentin and αSMA expression, including T3, and B3 in the CRC samples and T6 and B2 in the PDAC samples (Fig. 4C). The gene discussed is ACTA1; the disease is neoplasm.