To identify hybrid cells in patient-matched tumor and peripheral blood, we applied a small panel of Ab-oligos against CD45, a pan-leukocyte marker, and an epithelial cocktail containing Ab-oligos to EpCAM, ECAD, and pan-Cytokeratin (panCK) to CRC and PDAC tumor tissue and matched isolated PBMCs. Here, PTPRC is linked to colorectal carcinoma.