Moreover, hybrid cells from the tumor tissue versus those in blood predominantly harbored distinct cellular phenotypes (including upregulated CD45 and CD44 (T1 CRC; T7 PDAC) and ECAD (T1 CRC; T1 PDAC); and discrete phenotype in peripheral blood (i.e., upregulated expression of CK8 B7 CRC and B1 PDAC), which may indicate that discrete properties are required for hybrid cell dissemination into peripheral blood. The gene discussed is KRT8; the disease is colorectal carcinoma.