STAT3 and cancer: We explored the potential mechanism of GCSF (CSF3), GCSFR (CSF3R) and STAT3 in the pathogenesis of GBM from the dataset of patient samples of the TCGA Pan-Cancer Atlas database with the respective genetic alterations of GCSF (CSF3) 1.7%, GSCFR (CSF3R) 2.1% and STAT3 1.7% respectively (Fig. 4A).