Intriguingly, for IDH-wildtype glioma patients, we observed in all cases a distinct shift of hypoxic cells towards MES state (Fig. 5B), whereas among the IDH-mutant gliomas, the MES shift was largely absent; instead, we detected a strong shift towards an AC state in response to hypoxia (Fig. 5B). The gene discussed is IDH1; the disease is central nervous system cancer.