IDH1 and central nervous system cancer: To better understand the clinical relevance of the Shared Hypoxia DEGs of UCA and UNB (193 upregulated DEGs), we applied this hypoxia signature across glioma cells in 11 high-grade glioma patients, including 5 IDH-wildtype and 6 IDH-mutant gliomas based on a single cell RNA-seq dataset11.