By applying the Shared GBM Hypoxia signature to a larger single cell RNA-seq patient dataset, we revealed that IDH mutation status influences the responses of glioma cells to hypoxia, with IDH-wildtype glioma mainly shifting to a mesenchymal-like cell state, whereas IDH-mutant gliomas shifting more towards to an astrocyte-like state. This evidence concerns the gene IDH1 and central nervous system cancer.