For instance, for UCA, specific upregulated hypoxia DEGs included MMP2 and STC1, both linked to invasion and progression of gliomas16–18, while specific downregulated DEGs included NR1D2, the deficiency of which can promote cancer growth by activating inflammasome19, FRY, which suppresses the growth promoting transcription factor YAP20, and SOX21, which acts as a tumor suppressor of gliomas by inhibiting SOX2 expression and promoting differentiation of glioma cells21. The gene discussed is SOX21; the disease is glioma.