VEGFA and glioblastoma: By using the proportion of cells expressing VEGFA as a guide for hypoxia induction, we selected the Shared Hypoxia signature score of 0.25 as a threshold to separate cells into hypoxic versus non-hypoxic, with about 3.8% of GBM cells (1170 out of a total of 30,544) classified as hypoxic (Fig. 4B,C).