IARS1 and melancholia: Table 1 shows the sociodemographic and clinical data of the participants (controls and MDMD patients) divided into three groups using a PC extracted from 6 symptom domains (pure_depression, pure_anxiety, physiosomatic, insomnia, melancholia, and gastro-intestinal symptoms), and the major immune profiles (M1, Th-1, IRS, CIRS) and cytokines/chemokines (IL-16, TRAIL, CLC27, SCGF, M-CSF) (labeled: PC_immune + phenome) that differentiate controls from patients.