S100A8 and hydrops fetalis: Using cis-pQTLs effect estimates on S100A8/A9 levels from the validation cohort, increased genetically predicted S100A8/A9 levels were associated with increased risk of HF (IVW estimate of OR per SD: 1.04 [95% CI: 1.01–1.07]; P = 0.016) (Table 3).