We subsequently performed one-sample MR and observed that genetically predicted S100A8/A9 values were associated with HF (OR per SD: 1.20 [95% CI: 1.003–1.44], P = 0.047) after adjusting for age, sex, systolic blood pressure, Killip classification at admission, fasting glucose, creatinine, left main artery disease, neutrophil count, cTnI, BNP, CRP, LVEF at admission, and estimated infarct size (CK-MB AUC0–72). This evidence concerns the gene NPPB and hydrops fetalis.