In multivariate analysis, the association between S100A8/A9 and HF remained significant after adjustment for sex and significant clinical variables chosen from the univariable analysis (P < 0.05) (HR per SD: model 1: 2.05 [95% confidence interval [CI]: 1.80–2.35], P < 0.001; model 2: 2.15 [95% CI: 1.88–2.46], P < 0.001; model 3: 2.03 [95% CI: 1.77–2.33], P < 0.001) (Fig. 2b). Here, S100A8 is linked to hydrops fetalis.