MAPT and Parkinson disease: This genetic region plays a role in various neurodegenerative disorders related to mutations of the protein tau, such as frontotemporal dementia28 and progressive supranuclear palsy29, but also, of particular pertinence to the LIFO brain network, Alzheimer’s and Parkinson’s disease, with a genetic overlap between these two diseases in a locus included in our significant cluster 5 (rs393152, β = −0.09, P = 6.35 × 10−14)4.