The fourth locus was a SNP in chromosome 12, in an intron of NUAK1 (rs12146713, β = −0.10, P = 1.26 × 10−9), and remarkably its top association in UK Biobank was with the contrast between schizophrenia and major depressive disorder10, and it was also associated with insulin-like growth factor 1 levels (Table 1/Supplementary Data 1). This evidence concerns the gene NUAK1 and schizophrenia.