HE staining revealed that CIRP KO significantly alleviated pancreatic tissue damage in AP mice (Fig. 3I–K), as well as suppressed the upregulated serum levels of LDH, pro-inflammatory indicators (TNF-α and IL-6) (Fig. 3L–N), and amylase (Fig. 3O). This evidence concerns the gene CIRBP and alkaline phosphatase measurement.