In the pre-treatment serum samples from patients with HCC, the most frequent fusion transcript detected was MAN2A1–FER (100%, 61/61) (Table 1), followed by SLC45A2–AMACR and ZMPSTE24–ZMYM4 (both, 62.3%, 38/61). This evidence concerns the gene SLC45A2 and hepatocellular carcinoma.