The Fisher exact test showed that seven fusion genes—MAN2A1–FER (P = 1.4 × 10−19), CCNH–C5orf30 (P = 1.1 × 10−5), SLC45A2–AMACR (P = 2.8 × 10−9), ZMPSTE24–ZMYM4 (P = 9.3 × 10−6), PTEN–NOLC1 (P = 1.8 × 10−6), PCMTD1–SNTG1 (P = 0.006), and STAMBPL1–FAS (P = 0.01)—had significantly greater frequencies of expression in the serum samples of patients with HCC, suggesting that the detection of these fusion transcripts in the serum samples of patients with HCC likely predicts the risk for HCC. Here, ZMPSTE24 is linked to hepatocellular carcinoma.