Findings in the present study implicating 4EBP1 in mediating TNFR2-dependent tumor growth in ccRCC are that TNFR2 signaling increased the amount of phosphorylated 4EBP1 in ccRCC, in particular that of pSer65-4EBP1, a final key phosphorylation site that enables the complete dissociation of 4EBP1 from eiF4E26,49,50 and that it is associated with TNFR2 localization in mitochondria. The gene discussed is EIF4EBP1; the disease is nonpapillary renal cell carcinoma.