CRTC2 and cancer: One possibility is that TNFR2 mobilizes TORC2 as well as TORC1,66,67 and this pathway involves phosphorylation of Akt,68 which has previously been shown to be involved in driving TNFR2-mediated survival of CD133+ cancer stem-like cells together with vascular endothelial cell growth factor receptor type 2 and PI3K.7