RPS6KB1 and nonpapillary renal cell carcinoma: Torin 2 and Ku63794 significantly decreased the number of R2TNF-induced pSer65-4EBP1+/pH3S10+ double-positive tumor cells in ccRCC (Figure 6B), as quantified (Figure 6D), with a potency of approximately 8.4-fold for Torin 2 and approximately 5.25-fold for Ku63794, in keeping with their pharmacologic potency,30 whereas rapamycin did not inhibit cell cycle significantly, as expected as it blocks the ribosomal protein S6 kinase 1 (S6K1) pathway but not the 4EBP1 arm of mTORC1 signaling.30