COX5B and nonpapillary renal cell carcinoma: In organ cultures of ccRCC, stimulation by R2TNF caused a significant increase in Cox1, Cox4, and Cox5b expression compared with UT cultures (approximately 3.2-fold, approximately 3.7-fold, and approximately 2.7-fold, respectively) that co-localized in cells with elevated TNFR2, and a similarly significant increase in Cox1, Cox4, or Cox5b expression (approximately 3.7-fold, approximately 6.7-fold, and approximately 4.2-fold, respectively) that co-localized in cells with elevated pSer65-4EBP1 (Figure 4, A and B), quantified as CTCF (Figure 4C).