Thus, TNFR2-mediated signaling may be involved in the translational regulation of mitochondrial as well as in nuclear-encoded mitochondrial genes in ccRCC, with the former, perhaps, being mediated by mitochondrial-targeted TNFR2/pSer65-4EBP1. This evidence concerns the gene EIF4EBP1 and nonpapillary renal cell carcinoma.