Findings in the present study implicating 4EBP1 in mediating TNFR2-dependent tumor growth in ccRCC are that TNFR2 signaling increased the amount of phosphorylated 4EBP1 in ccRCC, in particular that of pSer65-4EBP1, a final key phosphorylation site that enables the complete dissociation of 4EBP1 from eiF4E26,49,50 and that it is associated with TNFR2 localization in mitochondria. Here, TNFRSF1B is linked to nonpapillary renal cell carcinoma.