TNFRSF1B and renal cell carcinoma: Total 4EBP1 was expressed in ccRCC tumor cells (positive for tumor marker RCC-MA27) irrespective of TNFR2 stimulation by R2TNF (percentage cell expression: UT, 45.0% ± 0.8%; R2TNF treated, 46.5% ± 1.2%) (Figure 2A).