Thus, TNFR2-mediated signaling may be involved in the translational regulation of mitochondrial as well as in nuclear-encoded mitochondrial genes in ccRCC, with the former, perhaps, being mediated by mitochondrial-targeted TNFR2/pSer65-4EBP1. The gene discussed is TNFRSF1B; the disease is nonpapillary renal cell carcinoma.