Since TRIM13 deletion also attenuated plasma lipoprotein levels in WD-fed ApoE−/− mice, it is possible that TRIM13, besides its involvement in curtailing cholesterol efflux and enhancing oxLDL uptake, might be involved in the development of hypercholesterolemia, which, however, needs further investigation. The gene discussed is APOE; the disease is familial hypercholesterolemia.