Furthermore, SOCS1/3 were found to be ubiquitinated and degraded in both aorta and peritoneal macrophages of ApoE−/− mice in response to WD and, as expected, these effects were blunted in WD-fed ApoE−/−:TRIM13−/− mice (Fig. 5, E and F). The gene discussed is APOE; the disease is Wilson disease.