CD8A and neoplasm: In contrast to our work where anti-CD8 antibodies had no effect on Keap1 mutant tumor growth (50), CD8 T cell depletion accelerated the growth of Keap1 R470C mutant tumors in the presence of DRP-104 (Fig. 3B), suggesting that DRP-104 can activate antitumor T cell responses against Keap1 mutant tumors.