In this aspect, we previously demonstrated that the HIF-1α/BNIP3 pathway could be one of the promising therapeutic targets in retinal degeneration in a murine model of retinal ischemia/reperfusion injury and unilateral common carotid artery occlusion, or a 661W photoreceptor cell line [28, 29, 51]. Here, BNIP3 is linked to retinal ischemia.