The findings of this meta-analysis are as follows: age, diabetes mellitus, renal disease, history of catheter-associated infection, hypertension, dialysis duration, catheter site, catheter duration, number of catheterizations, catheter type, CD4+ cell count, albumin level, C-reactive protein level, hemoglobin level, procalcitonin level, inadequate hand hygiene, and APACHE II scores were identified as risk factors for CRBSI in HD patients. This evidence concerns the gene CRP and diabetes mellitus.