The findings of this meta-analysis are as follows: age, diabetes mellitus, renal disease, history of catheter-associated infection, hypertension, dialysis duration, catheter site, catheter duration, number of catheterizations, catheter type, CD4+ cell count, albumin level, C-reactive protein level, hemoglobin level, procalcitonin level, inadequate hand hygiene, and APACHE II scores were identified as risk factors for CRBSI in HD patients. The gene discussed is CD4; the disease is Hypertension.