The author obtained disease-causing genes associated with childhood NB from the GeneCards database (https://www.genecards.org/) and analyzed the expression levels of two SNP genes and the expression levels of the top 20 genes in the Relevance score and observed that the expression levels of SNP genes were significantly correlated with the expression levels of several disease-associated genes, among which PELI2 was significantly positively correlated with PIK3CA (cor = 0.333) and MUC4 was significantly negatively correlated with FGFR1 (cor =  −0.209) (Fig. 2a, Supplementary File S1). This evidence concerns the gene PIK3CA and neuroblastoma.