However, based on a case-control study on 94,478 adult males (390 cases with ADHD) and 122,986 women (418 cases with ADHD) of the FinnGen cohort evidence for a directional effect of total testosterone in males and SHBG in both sexes for ADHD risk was found utilizing a latent causal variable [16]. Here, SHBG is linked to attention deficit-hyperactivity disorder.