AKT1 and cancer: KEGG pathway analysis revealed that the positively associated genes were closely related to the PI3K-Akt signaling pathway, chemokine signaling pathway, HIF-1 signaling pathway, and cell adhesion molecules (Figure 7E), while down-regulated genes were closely associated with the cAMP signaling pathway, MicroRNAs in cancer and WNT signaling pathway (Figure 7F).