Using one-way ANCOVA with CI and comorbid mood disorder or comorbid anxiety disorder as factors and age as a covariate, we found an interaction between CI and comorbid anxiety disorder (F1,25 = 4.103, p = 0.05, ηp2 = 0.141) and an interaction between CI and comorbid mood disorder (F1,25 = 6.432, p = 0.018, ηp2 = 0.205) in the plasma concentrations of sRAGE in AUD patients. The gene discussed is AGER; the disease is mood disorder.