HMGB1 and anxiety disorder: In addition, the effect of CI on the plasma HMGB1 concentrations remained significant when controlling for comorbid mood disorder (F1,23 = 4.316, p = 0.049, ηp2 = 0.152), and near significant when controlling for comorbid anxiety disorder (F1,24 = 3.591, p = 0.07, ηp2 = 0.130) in AUD patients.