AUD patients without CI (AUD-CI subgroup) had lower plasma concentrations of HMGB1 and NRF2 compared to the AD-CI subgroup (# p < 0.05; Figure 2A,E), as well as lower plasma NRF2 concentrations compared to control group (* p < 0.05; Figure 2E). The gene discussed is NFE2L2; the disease is Alzheimer disease.