APOD and cocaine dependence: We also observed a negative correlation between ROS/RNS and age of alcohol use onset (rho = −0.360, p = 0.039) and positive correlations between ApoD and alcohol abstinence duration (rho = 0.411, p = 0.023) and between ApoD and cocaine dependence onset (rho = 0.503, p = 0.048).