These interactions have been implicated in normal reproductive processes such as regulation of LH secretion [43,44] and sperm hyperactivation [45], as well as a number of maladies, including premenstrual dysphoric disorder, peripartum depression, catamenial epilepsy and polycystic ovary syndrome [46,47,48,49]. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.