HCRTR1 and colonic neoplasm: The binding of OXs with their cognate receptors is responsible for extensive apoptosis and a decrease in cell growth in numerous neoplastic cell lines, such as human colon cancer cells and human neuroblastoma cells [114], rat pancreatic cancer cells [115], rat glioma cells C6 [116], and Chinese hamster ovary transferred cells (CHO) with cDNA OX1R.