Previous studies utilizing murine AD-like models revealed that murine transcriptomes represent only 37%, 18%, 17%, and 11% of the human meta-analysis–derived atopic dermatitis profile (MADAD) for IL-23–injected, NC/Nga, oxazolone (OXA)-challenged, and ovalbumin (OVA)-challenged mice, respectively [22]. This evidence concerns the gene IL23A and atopic eczema.