Interestingly, there were 1198 overlapped DEGs (−1.5 ≥ FC ≥ 1.5 and FDR < 0.05) with moderate positive correlation (r = 0.53) between the transcriptome of anti-canine IgE skin lesions at 6-h and acute human AD in our study. The gene discussed is IGHE; the disease is Alzheimer disease.