IGHE and Alzheimer disease: Spearman correlation coefficient for the shared DEGs between canine anti-canine-IgE and human AD samples revealed a significant moderate positive correlation for anti-canine-IgE 6-h samples (1198 shared DEGs; r = 0.53; p < 0.001; Figure 4a) and 24-h samples (1020 shared DEGs; r = 0.47; p < 0.001; Figure 4b).