IGHE and Alzheimer disease: Although IgE-induced lesions did not capture all immune and barrier aspects of chronic spontaneous human AD, the results of this study demonstrate that acute IgE-mediated signaling in skin induces a wide array of inflammatory axes, including Th2 activation, and could be suited in pre-clinical studies to evaluate Th2 AD-centric axis and how it communicates with other activated immune responses in AD patients.