The deficiency of CTLA-4 is known as CTLA-4 haploinsufficiency with autoimmune infiltration (CHAI), while LRBA defects are termed “LRBA deficiency with autoantibodies, regulatory T (Treg) cell defects, autoimmune infiltration, and enteropathy” (LATAIE), emphasizing immune dysregulation as a major feature [36]. The gene discussed is CTLA4; the disease is Abnormal intestine morphology.