CASP10 and autoimmune lymphoproliferative syndrome: Autoimmune lymphoproliferative syndrome (ALPS), characterized by chronic lymphoproliferation, autoimmune manifestations, and an increased lymphoma risk, stems from defects in lymphocyte apoptosis, particularly in components of the apoptotic pathway (e.g., FAS, FASL, FADD, CASP10, and CASP8).