MAPT and Alzheimer disease: Two primary cardinal lesions often associated with AD are amyloid-beta (Aβ) plaques and neurofibrillary tangles (NFTs) containing hyperphosphorylated tau (hyper-p-tau), although the presence of Aβ and Tau cannot completely conclude AD, as there are cognitively unimpaired individuals who can have biomarker evidence of both Aβ and Tau pathology but will often not develop clinical manifestations in their lifetime [5].