During SARS-CoV-2 infection, there are potential mechanisms that may be involved in the development of AD and its corresponding sequelae, which comprise Aβ accumulation, genetic factors like the pathway of the APOE ε4, neuroinflammation (signatures such as cytokines of IL-6, IL-1, and Gal-3), and microglial activation. This evidence concerns the gene APOE and Alzheimer disease.