However, of the reports of Aβ peptide acting as an antimicrobial agent through its putative protective function as a trap for pathogens [82,83,84], the group of Drs. Zhang and Zheng explored this possible connection of ZIKV with AD and showed that APP is stabilized by interacting with ZIKV and also inhibits ZIKV replication in both human neuronal progenitor stem cells and in neuronal stem cells in neonatal mouse brains. This evidence concerns the gene APP and Alzheimer disease.