Studying the involved pathways and the differences with AD, they propose serum low-density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR) or CD91, involved in various biological processes via interactions with >100 different extracellular ligands and several intracellular proteins [53], as a candidate marker to differentiate AD and MixD [54]. This evidence concerns the gene LRP1 and Alzheimer disease.