The dark C1orf128 (PITHD1) protein, also known as uPE1 (C-terminal proteasome-interacting domain of thioredoxin-like) domain-containing protein 1, previously identified as a component of the human central proteome, plays a role in various biological processes such as megakaryopoiesis, ovarian carcinoma, and male fertilization. Here, PITHD1 is linked to ovarian carcinoma.