The findings of the study demonstrated that the combination of curcumenol and 34 could inhibit the proliferation and metastasis of liver cancer cells in vivo and in vitro by inhibiting endogenous H2S production and downregulating the pSTAT3/BCL-2 and VEGF pathways, providing strong evidence for the application of curcumenol and 34 in liver cancer treatments. Here, VEGFA is linked to liver cancer.