Moreover, it was also reported that 24 exhibits cytotoxicity against metastatic human bladder cancer cell lines (TSU-Pr1, TSU-Pr1-B1, and TSU-Pr1-B2) and the superficial bladder cancer cell line 5637 with an IC50 ranging from 3.76 to 4.56 μM against the TSU-Pr1 series and 10 μM against 5637 cell lines [171]. Here, TMEM37 is linked to urinary bladder cancer.