IL-15 is essential for the activation of NK cells and CD8+ T lymphocytes; its activation uses a common cytokine receptor (CD132), which coactivates other cytokines (IL-2, IL-4, IL-7, IL-9, and IL-21), a receptor called β that activates IL2/IL-15, and a third one which is activated through the Janus kinase pathway; its overactivation has been related to both autoimmune diseases and lymphoid neoplasms [4]. The gene discussed is IL2; the disease is autoimmune disease.